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Hypertrophic Obstructive Cardiomyopathy During Pregnancy: A Report of Two Cases
Pedro A Román1, Carlos M Penate2, Gleiny Vázquez1
1Heart Disease and Pregnancy, Hospital Materno Ramón González Coro, Havana, CUB.
Cureus
|February 27, 2026
Summary
Pregnancy in women with hypertrophic obstructive cardiomyopathy (HOCM) can worsen left ventricular outflow tract obstruction (LVOTO). Careful hemodynamic monitoring and specialized care are crucial for managing pregnant patients with HOCM.
Area of Science:
- Cardiology
- Genetics
- Reproductive Medicine
Background:
- Hypertrophic cardiomyopathy (HCM) is a genetic condition affecting sarcomeric proteins, leading to left ventricular (LV) wall thickening.
- Hypertrophic obstructive cardiomyopathy (HOCM) is a phenotype of HCM characterized by dynamic LV outflow tract (LVOT) obstruction, often due to septal hypertrophy and mitral valve abnormalities.
- While generally well-tolerated, pregnancy in HCM patients can be complicated by significant LV outflow tract obstruction (LVOTO).
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