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Updated: Feb 28, 2026

Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization
Published on: November 29, 2018
Photocatalytic multicomponent alkene dicarbofunctionalization via PCET/nickel dual catalysis
Yeersen Patehebieke1, Victoria Jansson1, Jakob Öberg1
1Department of Chemistry and Molecular Biology, University of Gothenburg Gothenburg SE 41390 Sweden carl.wallentin@chem.gu.se.
None:
Herein we report a synergistic photoredox PCET/nickel dual catalytic strategy that enables three-component alkene dicarbofunctionalization (DCF) using unprotected alcohols as alkyl radical precursors. This transformation merges concerted proton-coupled electron transfer (PCET) activation of alcohols with nickel-catalyzed cross-coupling, achieving sequential Giese addition and C(sp3)-C(sp3), C(sp3)-C(sp2) bond formation under visible light and redox-neutral conditions. The method proceeds directly from secondary and tertiary alcohols, exhibits broad functional-group tolerance. Notably, employing a chiral Ni catalyst enables the first enantioselective variant of this type of PCET mediated transformation. This work establishes a general platform for deconstructive alkene difunctionalization from simple alcohol feedstocks, expanding the synthetic reach of PCET in dual catalytic radical chemistry.
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