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Ornidazole neurotoxic footprint: a comprehensive paediatric case report with follow up imaging
Chandrika Sachar1, Purnima Aggarwal1
1Department of Radiodiagnosis, Government Medical College and Hospital, Chandigarh, India.
Insights
Rare ornidazole neurotoxicity occurred in a child presenting with ataxia and weakness. Prompt diagnosis and drug cessation led to symptom resolution, highlighting the need for careful medication review in pediatric patients.
Area of Science:
- Pediatric Neurology
- Toxicology
- Radiology
Background:
- Nitroimidazoles like ornidazole are common in pediatric care.
- Neurotoxicity from ornidazole is rare but reported.
- Prompt recognition is crucial for patient outcomes.
Abstract:
Nitroimidazoles, such as metronidazole and ornidazole, are widely used in pediatric patients, yet rare cases of ornidazole neurotoxicity have been reported. We present a 7-year-old boy who developed acute weakness, ataxia, and slurred speech after taking an over-the-counter tablet containing ornidazole drug for abdominal pain and diarrhea. Magnetic resonance imaging (MRI) showed symmetrical hyperintensities in the dentate nuclei, indicating a possible demyelinating or toxic condition. Ornidazole-induced neurotoxicity was confirmed based on clinical history and improvement upon drug discontinuation. Follow-up MRI after 2 months showed near-complete resolution. This case highlights the importance of recognizing ornidazole toxicity, understanding its specific imaging characteristics, and emphasizes the need for early diagnosis and careful medication review to avoid unnecessary investigations.
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