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Association of lipoprotein(a), oxidized phospholipids and apolipoprotein B100 in acute ischemic stroke cohort

Yihao Li1, Emmie Then1, Salwa Rahman2

  • 1Department of Medicine, Division of Preventive Medicine and Nutrition, Columbia University Vagelos College of Physicians and Surgeons, 630 West 168th Street, P & S 8-503, New York, NY 10032, USA.

Advances in Lipoprotein(A) Research
|February 27, 2026
PubMed

Insights

High lipoprotein(a) [Lp(a)] levels and specific Lp(a) biomarkers are linked to atherosclerotic stroke. These findings highlight Lp(a) as a key factor in stroke development, particularly extracranial atherosclerotic disease (ECAD).

Area of Science:

  • Cardiovascular Science
  • Neurology
  • Biomarkers

Background:

  • Atherosclerosis in major arteries is a leading cause of stroke.
  • Elevated lipoprotein(a) [Lp(a)] levels are implicated in atherosclerotic stroke, particularly intracranial disease.
  • The specific role of Lp(a) in different ischemic stroke subtypes requires further clarification.

Purpose of the Study:

  • To investigate the association between Lp(a)-related biomarkers and ischemic stroke subtypes.
  • To clarify the role of Lp(a) in the pathogenesis of atherosclerotic stroke.

Main Methods:

  • Analysis of plasma samples from 244 acute ischemic stroke patients.
  • Measurement of Lp(a) concentrations, apolipoprotein B100 (APOB), and oxidized phospholipids (OxPL) using ELISA.
  • Determination of APO(a) isoform size via gel electrophoresis and stroke subtype classification.

Main Results:

  • High Lp(a) concentrations, percentage of APOB in Lp(a), and OxPL-APO(a) were significantly associated with atherosclerotic stroke.
  • These biomarkers were also significantly associated with extracranial atherosclerotic stroke (ECAD).

Conclusions:

  • Lp(a) concentration, APOB percentage within Lp(a), and OxPL-APO(a) are positively linked to acute atherosclerotic ischemic stroke.
  • These findings underscore the role of Lp(a) and its modifications in the development of atherosclerotic stroke, especially ECAD.
Abstract

Keywords:
Lp(a)acute ischemic strokeoxidized phospholipids

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