Vaginal Ulcers Secondary to Stage Iv Uterine Prolapse Treated With L-PRF

Area of Science:

• Gynecology
• Regenerative Medicine

Background:

• Pelvic organ prolapse (POP) involves pelvic organs descending into or through the vagina, leading to complications like bleeding, discharge, and pain.
• While surgery is common for younger patients, older women with comorbidities may face challenges with advanced POP.
• Chronic non-healing ulcers can develop in cases of severe POP, particularly with incontinence, complicating management.

Purpose of the Study:

• To evaluate the efficacy of Leukocyte- and Platelet-Rich Fibrin (L-PRF) in treating uterine ulcers in a non-surgically treatable, elderly obese patient with Stage IV uterine prolapse.

Main Methods:

• A 93-year-old obese female patient with Stage IV uterine prolapse and multiple vaginal ulcers due to incontinence was treated.
• The ulcerated areas were infiltrated with L-PRF membranes and covered with Platelet-Rich Fibrin (PRF).
• The PRF was sutured and protected, with the ulcer area covered with an inverted glove.

Main Results:

• The case report demonstrated a positive therapeutic effect of L-PRF on the uterine ulcers.
• This suggests L-PRF is a promising treatment for vaginal ulcers associated with pelvic organ prolapse.
• The treatment showed efficacy, safety, and cost-effectiveness compared to conventional dressings.

Conclusions:

• L-PRF shows significant potential as an effective treatment for chronic, non-healing uterine ulcers.
• It offers advantages over traditional wound dressings for managing vaginal ulcers in POP patients.
• This approach provides a viable, less invasive option for specific patient populations with advanced POP.