Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neural Circuits01:25

Neural Circuits

3.0K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MediLabSecure: A One Health Network Facing the COVID-19 Pandemic DVM.

Health security·2026
Same author

The kisspeptin analog C6 elicits greater tachyphylaxis and transcriptional activation than kisspeptin-10 and -54.

Molecular and cellular endocrinology·2026
Same author

Orthogonally constrained CASSCF framework: Newton-Raphson orbital optimization and nuclear gradients.

The Journal of chemical physics·2026
Same author

Stochastic Difference-Dedicated Configuration Interaction for Magnetic Exchange in Large Active Spaces.

Journal of chemical theory and computation·2026
Same author

Purinergic signaling promotes gliomagenesis through nuclear calcium transients.

bioRxiv : the preprint server for biology·2026
Same author

Rapid Methylthiolation of (Hetero)Aryl Halides at Room Temperature Using Sodium Thiomethoxide via Palladium-Catalysis.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026

Related Experiment Video

Updated: May 5, 2026

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit
11:37

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Published on: August 2, 2017

10.4K

Temporal Coding rather than Circuit Wiring allows Hippocampal CA3 Neurons to Dynamically Distinguish Different

Keelin O'Neil1,2, Vincent Robert1, Luke A Arend1,2

  • 1Institute for Translational Neuroscience, New York University Langone Health, New York, NY 10016, USA.

Biorxiv : the Preprint Server for Biology
|February 27, 2026
PubMed
Summary

Hippocampal CA3 neurons integrate information from the medial and lateral entorhinal cortices (MEC and LEC). Findings show temporal coding, not circuit structure, underlies how CA3 processes this multisensory memory data.

More Related Videos

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice
07:10

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Published on: July 1, 2018

9.4K
Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

13.5K

Related Experiment Videos

Last Updated: May 5, 2026

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit
11:37

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Published on: August 2, 2017

10.4K
Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice
07:10

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Published on: July 1, 2018

9.4K
Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

13.5K

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • Memory formation requires associating and indexing multimodal information, a process not fully understood at the single-neuron level.
  • The hippocampus integrates information from the medial entorhinal cortex (MEC) and lateral entorhinal cortex (LEC) for environmental representations.
  • The precise synaptic dynamics, circuit organization, and integrative functions of MEC and LEC inputs to the hippocampus remain largely unknown.

Purpose of the Study:

  • To investigate how single CA3 pyramidal neurons in the hippocampus integrate multisensory information from MEC and LEC.
  • To elucidate the synaptic dynamics and circuit organization of MEC and LEC inputs onto CA3 neurons.
  • To determine the functional consequences of differential MEC and LEC input processing within the hippocampus.

Main Methods:

  • Dual-color optogenetic circuit mapping was employed to trace and analyze MEC and LEC inputs to CA3 pyramidal neurons.
  • Input-output functions and modulation by GABAergic microcircuitry were assessed for both MEC and LEC inputs.
  • Frequency-dependent short-term plasticity of synaptic responses was characterized for MEC and LEC inputs.
  • In vivo recordings examined the relationship between MEC-originating dentate spikes, CA3 firing, and oscillatory activity.

Main Results:

  • Contrary to segregation models, both MEC and LEC inputs converge on nearly all CA3 pyramidal neurons with similar input-output functions.
  • Synaptic plasticity differs significantly: LEC inputs depress at high frequencies, while MEC inputs continue to facilitate.
  • In vivo, MEC-originating dentate spikes drive CA3 pyramidal neurons more than LEC inputs, linked to distinct oscillatory timing.

Conclusions:

  • Hippocampal area CA3 processes region-specific information from MEC and LEC primarily through temporal coding mechanisms.
  • This temporal coding strategy operates at both single-neuron and network levels, challenging traditional views of hard-wired circuit organization.
  • The findings provide novel insights into the neural basis of associative memory and environmental representation in the hippocampus.