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Updated: Feb 28, 2026

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

Published on: June 17, 2025

Bull Fertility and Epigenetics: Exploring Influences Beyond Genetics.

Manisha Sethi¹, Tushar Kumar Mohanty¹, Nadeem Shah²

¹Animal Reproduction, Gynaecology and Obstetrics, Artificial Breeding Research Centre (ABRC), ICAR-National Dairy Research Institute, Karnal, Haryana, India.

Reproduction in Domestic Animals = Zuchthygiene

|February 27, 2026

Summary

This summary is machine-generated.

Epigenetics offers new insights into male infertility, revealing how DNA methylation, histone modifications, and non-coding RNAs impact fertility across generations. These epigenetic markers can differentiate between high- and low-fertility bulls.

Keywords:

bull epigenetics fertility maternal nutrition sperm toxins

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Analysis of Epididymal Protein Synthesis and Secretion

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Published on: August 25, 2018

Area of Science:

Reproductive Biology
Epigenetics
Animal Science

Background:

Male infertility affects humans and farm animals, with genetics explaining only a small fraction of cases.
Epigenetics, studying heritable gene expression changes without altering DNA sequence, offers a promising avenue to understand infertility.
Key epigenetic mechanisms include DNA methylation, histone modifications, and non-coding RNA regulation.

Purpose of the Study:

To explore the role of epigenetics in male infertility, particularly in cattle.
To investigate how environmental and nutritional factors influence the sperm epigenome in bulls.
To identify potential epigenetic biomarkers for predicting bull fertility.

Main Methods:

Analysis of DNA methylation patterns in bull sperm.
Assessment of histone modifications associated with fertility.
Quantification of non-coding RNA expression in high- and low-fertility bulls.

Main Results:

Epigenetic modifications differ significantly between high- and low-fertility bulls.
Environmental factors and maternal nutrition can impact the bull's sperm epigenome.
These epigenetic changes exhibit transgenerational effects on fertility.

Conclusions:

Epigenetic biomarkers, including DNA methylation, histone modifications, and non-coding RNAs, can distinguish between bulls of varying fertility.
Understanding these epigenetic factors is crucial for improving cattle breeding and fertility management.
Epigenetic analysis presents a novel approach for predicting and potentially managing male fertility.