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Updated: Feb 28, 2026

ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly
Published on: April 17, 2014
Nanoscale opportunities in extracellular matrix mimicry
L Andrew Lyon1,2,3, Abbygail Caine1,2,4, Elif Narbay2
1Schmid College of Science and Technology, Chapman University, Orange, CA 92866, USA.
Abstract:
We present an overview of the composition, function, energetics, and dynamics of extracellular matrix and its relation to nanoscale structures and phenomena. These concepts are then related to the development of synthetic and biosynthetic materials that aim to mimic the extracellular matrix for regenerative medicine and tissue engineering technologies. Notable successes and advancements towards the goal of biomimicry are outlined, while remaining challenges and knowledge gaps towards that goal are highlighted. Finally, we frame the remaining challenges in the field in terms of nanoscience-related research opportunities that if solved, might prove to be transformative steps forward in the discipline.
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