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Updated: Feb 28, 2026
A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Co-N2P2 single-atom catalysts enable efficient α-alkylation of aromatic ketones
Natarajan Anbuselvan1, Selvam Sivaprakash1, Duraiarasan Sneha1
1Department of Chemistry, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, Tamil Nadu, 613 401, India. suresh_d@scbt.sastra.edu.
Researchers developed novel single-atom sites for efficient chemical reactions. Cobalt-nitrogen-phosphorus (Co-N2P2) sites catalyze the α-alkylation of aromatic ketones.
Area of Science:
- Materials Science
- Catalysis
- Organic Chemistry
Background:
- Single-atom catalysis offers high efficiency and selectivity.
- Developing stable and active single-atom sites remains a challenge.
- Covalent triazine polymers are promising supports for catalysts.
Purpose of the Study:
- To synthesize and characterize novel single-atom sites for catalytic applications.
- To investigate the catalytic activity of these sites in α-alkylation reactions.
- To explore the potential of cobalt-based single-atom catalysts.
Main Methods:
- Carbonization of cobalt precursor (Co(PPh3)2Cl2) on a covalent triazine polymer.
- Characterization using advanced spectroscopic and microscopic techniques.
- Testing the catalytic performance in the α-alkylation of aromatic ketones.
Main Results:
- Successfully generated Co-N2P2 single-atom sites anchored on the polymer support.
- Achieved highly efficient α-alkylation of aromatic ketones.
- Demonstrated the stability and reusability of the catalyst.
Conclusions:
- The synthesized Co-N2P2 single-atom sites are effective catalysts for α-alkylation.
- This work highlights the potential of covalent triazine polymers as supports for single-atom catalysts.
- Provides a new route for designing advanced catalytic materials.
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