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Updated: Jun 20, 2026

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
Published on: June 7, 2015
Cyclic peptide-based shear-thinning and self-healing hydrogels as injectable nanotherapeutics
Fátima Santillán1, Yasmeen Shamiya1, Aishik Chakraborty2
1Department of Chemistry, Western University, 1151 Richmond St, London, Ontario, N6A 5B7, Canada. arghya.paul@uwo.ca.
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An injectable cyclic peptide-based hydrogel (cpGel) governed by supramolecular interactions between cyclic octapeptide nanofibers and LAPONITE® was developed. We demonstrated its excellent injectability, elasticity, and self-healing properties through rheological analyses. Further, we showed that cpGel is cytocompatible and that vancomycin-loaded cpGel can effectively inhibit the growth of MRSA and E. coli.
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