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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

586
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
586
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

559
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
559

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Related Experiment Video

Updated: Feb 28, 2026

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation
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Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

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Risk Factors for Failure to Rescue in Adult Liver Transplantation Recipients: A Systematic Review.

Jiro Kimura1, Badi Rawashdeh1, Ayham Asassfeh1

  • 1Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Clinical Transplantation
|February 27, 2026
PubMed
Summary
This summary is machine-generated.

Failure to rescue (FTR) after liver transplantation is poorly understood. Key risk factors include sarcopenia, early allograft dysfunction, and center volume, but standardized definitions are needed for better outcomes.

Keywords:
failure to rescueliver transplantationmortalityrisk factorsystematic review

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Related Experiment Videos

Last Updated: Feb 28, 2026

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation
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Area of Science:

  • Hepatology
  • Transplantation Surgery
  • Quality Improvement in Healthcare

Background:

  • Failure to rescue (FTR), defined as death following major complications, is a critical quality metric.
  • Liver transplantation (LT) has high risks for postoperative complications, yet FTR relevance and determinants in LT are poorly characterized.

Purpose of the Study:

  • To systematically review the incidence and risk factors for FTR in adult liver transplant recipients.

Main Methods:

  • Systematic literature search following PRISMA guidelines across four major databases (MEDLINE, Web of Science, Cochrane CENTRAL, Scopus).
  • Inclusion of studies reporting FTR rates and associated risk factors in adult LT recipients.
  • Independent data extraction and quality assessment by two reviewers.

Main Results:

  • Four studies (13,710 LT cases) were included, showing heterogeneous FTR incidence (5.0%–39.6%) due to varied definitions.
  • Identified risk factors: low total psoas area (sarcopenia), increased recipient age, early allograft dysfunction, and low-volume transplant centers.
  • One study noted FTR variation across Human Development Index levels, but lacked individual-level predictors.

Conclusions:

  • Evidence on FTR in liver transplantation is limited, hindering robust conclusions.
  • Sarcopenia, early allograft dysfunction, and socioeconomic disparities may influence FTR.
  • Standardized FTR definitions and multicenter prospective studies are crucial for identifying modifiable factors and improving outcomes.