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Updated: Feb 28, 2026

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
Published on: March 15, 2024
A lipid droplet-targeted Pt(II) complex enables photoinduced ferroptosis and apoptosis against cisplatin-resistant
Puzhen Hui1, Fengwu Xu2, Huilin Zheng1
1Anhui Innovative Center for Drug Basic Research of Metabolic Diseases, School of Pharmacy, Wannan Medical College, Wuhu 241002, China. guxiaoxia@wnmc.edu.cn.
Abstract:
The development of metal complex-based photosensitizers that can precisely regulate cell fate via lipid droplet (LD)-mediated pathways remains challenging. Herein, an LD-specific targeting Pt(II) complex was designed to address this limitation by directly inducing sufficient lipid peroxidation (LPO) accumulation, offering a novel platform for synergistic ferroptosis-apoptosis cancer therapy. This work provides a novel anticancer platform using photoactivated platinum complexes to concurrently trigger dual cell death pathways.

