Associations of Endothelial-Related lncRNAs with Early-Onset STEMI: A Case-Control Study

Early-onset ST-segment elevation myocardial infarction (STEMI) in individuals under 50 is an increasing concern. Identifying new biomarkers could improve early diagnosis and intervention. In this case-control study, we investigated endothelial-related long non-coding RNAs (lncRNAs) MANTIS, NORAD, RNCR3, and SENCR as potential diagnostic markers. Blood samples from 200 young STEMI patients and 200 age-matched controls were analyzed using real-time PCR to evaluate lncRNA expression. NORAD and MANTIS levels were significantly reduced in STEMI patients (p < 0.001). MANTIS displayed the strongest association (AUC = 0.92), while NORAD demonstrated a moderate association (AUC = 0.68). SENCR and RNCR3 showed no significant differences between groups. The downregulation of MANTIS and NORAD suggests their potential roles as biomarkers in early-onset STEMI. MANTIS, in particular, may enhance risk stratification and treatment. Further research is warranted to validate these findings in broader populations.