Related Experiment Video
Updated: Feb 28, 2026

Retinal Pathophysiological Evaluation in a Rat Model
Published on: May 6, 2022
Therapeutic potential of prolactin-releasing anti-dopaminergic agents in experimental diabetic retinopathy model
Kubra Peker1, Ayse Ipek Akyuz Unsal2, Ibrahim Meteoglu3
1Department of Ophthalmology, Faculty of Medicine, Aydin Adnan Menderes University, Aydin, Turkey.
Key Messages:
WHAT IS KNOWN : • Anti-dopaminergic agents (metoclopramide (MCP), trimethobenzamide (TMB), and domperidone (DOM)) are used for diabetic gastroparesis, but their effects on diabetic eye are not well studied.
What Is New:
• These drugs do not affect intraocular pressure or tear production in diabetic rats. • They increase retinal prolactin receptor expression and reduce VEGF and CD31 immunoreactivity, indicating modulation of angiogenesis-related markers in the diabetic retina. • These findings may encourage future research to explore the potential role of prolactin-elevating antidopaminergic agents in diabetic retinopathy.

