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A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

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Programmable On-Chip Manipulation and Separation of Biological Cells Using a Rotating AC-FFET Platform.

Wanping Gao^1,2, Yupan Wu^1,2,3,4, Yuanbo Yue²

¹School of Integrated Circuits, Southeast University, Wuxi 214000, China.

Analytical Chemistry

|February 27, 2026

Summary

This summary is machine-generated.

This study introduces a novel bipolar electrode-associated micromotor propulsion (BAMP) platform for precise, contactless manipulation of biological entities. The system enables programmable cell control, sorting, and separation using electric fields, advancing biomedical research and microdevices.

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Area of Science:

Microfluidics and Nanotechnology
Biomedical Engineering
Cellular Manipulation

Background:

Precise manipulation of micro/nanoscale biological entities is crucial for biomedical applications.
Existing methods often lack programmability, selectivity, or require physical contact and labeling.
This limits their use in complex biological environments.

Purpose of the Study:

To develop a novel platform for programmable, contactless manipulation of biological entities.
To enable cell enrichment, trajectory steering, and separation using electric field modulation.
To demonstrate label-free cell sorting based on dielectric properties.

Main Methods:

Utilized a bipolar electrode-associated micromotor propulsion (BAMP) platform.
Employed a rotating alternating current-flow field effect transistor (ROT-FFET) for electric field control.
Dynamically reconfigured induced-charge electroosmotic (ICEO) flow and dielectrophoretic (DEP) forces.

Main Results:

Achieved real-time manipulation of synthetic particles and live cells (yeast, 293T, red blood cells) up to 3.5 μm s^-1.
Demonstrated programmable control of cell enrichment, trajectory steering, and separation.
Successfully performed contactless, label-free cell sorting by exploiting dielectric properties.

Conclusions:

The BAMP platform offers precise, programmable, and contactless control of micro/nanoscale biological entities.
This technology has broad applicability in additive manufacturing, microrobotics, and biomedical microdevices.
Future work can integrate directed motion for bottom-up fabrication of complex structures.