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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Better, not just fewer: Rethinking antibiotic prescribing.

Giorgia Sulis1,2, Derek R MacFadden1,3

  • 1School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.

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|February 27, 2026
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Summary
This summary is machine-generated.

Clinical decision support tools can reduce unnecessary antibiotic prescriptions. Addressing behavioral, equity, and governance issues is crucial for tackling antimicrobial resistance and promoting "better, not just fewer" antibiotic uses.

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Area of Science:

  • Public Health
  • Infectious Diseases
  • Health Informatics

Background:

  • Antimicrobial resistance (AMR) is a significant global health threat.
  • Clinical decision support (CDS) tools can help optimize antibiotic prescribing.
  • Technological solutions alone are insufficient to curb unnecessary antibiotic use.

Purpose of the Study:

  • To explore the multifaceted challenges in combating antimicrobial resistance.
  • To highlight the importance of behavioral, equity, and governance factors.
  • To advocate for a "better, not just fewer" approach to antibiotic prescribing.

Main Methods:

  • Review of existing literature on CDS tools and AMR.
  • Analysis of behavioral, equity, and governance barriers.
  • Synthesis of evidence to support a comprehensive strategy.

Main Results:

  • Success of CDS tools is contingent upon addressing non-technical factors.
  • Behavioral patterns significantly influence prescribing habits.
  • Equity considerations are vital for effective AMR interventions.
  • Robust governance frameworks are necessary for sustainable antibiotic stewardship.

Conclusions:

  • A holistic approach integrating technology with behavioral, equity, and governance strategies is essential for effective antimicrobial resistance containment.
  • Focusing on "better, not just fewer" antibiotic prescriptions ensures optimal patient outcomes and preserves antibiotic efficacy.