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Using virtual reality hypnosis during stem cell transplant for patients in hematology: A protocol for a feasibility
Audrey Laurin1,2, Floriane Rousseaux2,3, Valentyn Fournier2,3,4
1Department of Psychology, Faculty of Arts and Sciences, University of Montreal, Montreal, Canada.
Plos One
|February 27, 2026
Summary
This study tests virtual reality hypnosis (VRH) for hematological cancer patients undergoing stem cell transplant. VRH shows promise in reducing patient anxiety, pain, and fatigue, improving their quality of life.
Area of Science:
- Oncology
- Psychology
- Medical Technology
Background:
- Stem cell transplantation causes significant distress for cancer patients, impacting quality of life.
- Hypnosis and virtual reality (VR) show potential for symptom management in cancer care.
- Combining VR with hypnosis (VRH) may enhance patient support, but requires further investigation.
Purpose of the Study:
- To evaluate the preliminary impact of VRH on anxiety, pain, and fatigue during stem cell transplant.
- To assess the effect of VRH on patients' quality of life post-intervention.
- To determine the feasibility and patient satisfaction with the VRH tool.
Main Methods:
- A randomized controlled trial comparing VRH to a waiting list control group in 60 hematology patients.
- Assessment of anxiodepressive symptoms, pain, quality of life, and fatigue using validated scales.
- Collection of patient experiences and feedback through semi-structured interviews.
Main Results:
- Preliminary data will be collected on the effectiveness of VRH in symptom reduction and quality of life improvement.
- Feasibility and usability data will be gathered to refine the VRH tool.
- Statistical analysis will include MANOVA and thematic analysis of qualitative data.
Conclusions:
- This feasibility RCT aims to assess VRH's effectiveness against standard care for stem cell transplant patients.
- Findings will inform the development of an improved VRH tool (version 2.0).
- The long-term goal is to integrate VRH into clinical practice for enhanced patient support.

