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Multimodal Study of Murine Cardiovascular Remodeling: Four-Dimensional Ultrasound and Mass Spectrometry Imaging

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Multimodal Imaging in Lipemia Retinalis.

Rouzbeh Abbasgholizadeh^1,2, Mai Alhelaly^1,2,3, Alberto Quarta^1,2,4

¹Doheny Eye Institute, Pasadena, CA, USA.

Retinal Cases & Brief Reports

|February 27, 2026

Summary

Lipemia retinalis, a sign of high triglycerides, is reversible with prompt lipid-lowering therapy. Ultra-widefield imaging and OCT help document its development and resolution, aiding in preventing pancreatitis.

Keywords:

Lipemia Retinalis Multimodal Imaging Retina

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Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

Published on: August 4, 2018

Area of Science:

Ophthalmology
Medical Imaging
Endocrinology

Background:

Lipemia retinalis is a rare condition characterized by creamy-white retinal vasculature.
It is a sign of severe hypertriglyceridemia, often associated with conditions like diabetes.
This case highlights the importance of recognizing and managing this ophthalmic manifestation of metabolic derangement.

Purpose of the Study:

To detail the multimodal imaging findings in a patient with lipemia retinalis.
To illustrate the progression and resolution of lipemia retinalis.
To emphasize the role of advanced imaging in managing severe hypertriglyceridemia.

Main Methods:

Utilized ultra-widefield (UWF) pseudocolor and autofluorescence imaging.
Employed UWF optical coherence tomography (OCT) for cross-sectional imaging.
Performed fluorescein angiography, indocyanine green angiography, and UWF OCT angiography to assess vascular perfusion.

Main Results:

Severe hypertriglyceridemia (5,885 mg/dL) and hypercholesterolemia (876 mg/dL) were diagnosed.
UWF imaging showed diffuse creamy-white retinal vessels; OCT revealed vascular lumen hyperreflectivity.
Lipid-lowering therapy normalized triglyceride levels to 167 mg/dL and cholesterol to 148 mg/dL within one month, resolving imaging findings.

Conclusions:

Lipemia retinalis is a reversible condition linked to intravascular chylomicronemia.
UWF imaging and OCT are valuable tools for documenting and monitoring lipemia retinalis.
Early diagnosis and systemic treatment are crucial to prevent pancreatitis and cardiovascular events.