Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Engineering a dual-antigen mRNA vaccine to restore immune control in chronic hepatitis B.

Nature communications·2026

Same author

Nanoparticles reach metastatic tumours via enhanced permeability of adjacent vessels.

Nature nanotechnology·2026

Same author

Lanmodulin-Engineered Outer Membrane Vesicles for Synergistic Targeted Radio-Immunotherapy.

ACS nano·2026

Same author

Mucoadhesive tumor-penetrating nanomedicine for intravesical chemo-immunotherapy against bladder cancer.

Science advances·2026

Same author

Nanomedicine and Biomaterial Platforms for Photoimmunotherapy.

Angewandte Chemie (International ed. in English)·2026

Same author

Commensal-driven serotonin production modulates in vivo delivery of synthetic and viral vectors.

Science (New York, N.Y.)·2026

Same journal

Linker Engineering toward NIR-II Metal-Organic Framework with Maximal Emission beyond 1000 nm for Inflammatory Bowel Disease Imaging.

Journal of the American Chemical Society·2026

Same journal

Observing Kinetic Selectivity in Anthracene Photodimerization through Selective Quenching by Excited States of Proximate Rare Earth Cations.

Journal of the American Chemical Society·2026

Same journal

Sequence-Dependent Folding of Recognition-Encoded Melamine Oligomers.

Journal of the American Chemical Society·2026

Same journal

Large Thermo- and Mechanosalient Actuation via Cooperative Twist Elasticity-Induced Packing Motif Conversion.

Journal of the American Chemical Society·2026

Same journal

Discovery and Biosynthesis of Lanthipeptides Featuring an Azepinoindole Scaffold by Radical <i>S</i>-Adenosylmethionine Enzyme-Catalyzed C-C Bond Formation.

Journal of the American Chemical Society·2026

Same journal

Enantiopurity-Controlled Magnetism in a Two-Dimensional Organic-Inorganic Material.

Journal of the American Chemical Society·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 1, 2026

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo

Published on: February 5, 2019

Engineering Polymer-Lipid Integrated Nanoparticles with Quantitative Design Principles for Organ-Selective mRNA

Qin Wang¹, Shanshan Chen², Gang Li²

¹Macao Institute of Materials Science and Engineering, Macau University of Science and Technology, Taipa , Macau SAR 999078, China.

Journal of the American Chemical Society

|February 27, 2026

Summary

This summary is machine-generated.

Researchers developed a new framework using design of experiments and predictive modeling to engineer polymer-lipid nanoparticles (PLINs) for precise mRNA delivery. This approach enables highly organ-selective targeting, improving therapeutic outcomes.

More Related Videos

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA

Published on: February 1, 2019

Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting

Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting

Published on: June 18, 2018

Related Experiment Videos

Last Updated: Mar 1, 2026

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo

Published on: February 5, 2019

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA

Published on: February 1, 2019

Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting

Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting

Published on: June 18, 2018

Area of Science:

Biotechnology and Nanomedicine
Drug Delivery Systems
Molecular Therapeutics

Background:

Therapeutic mRNA success hinges on effective in vivo delivery systems for organ-selective targeting.
Current empirical screening methods struggle with the nonlinear relationships between nanoparticle composition and delivery outcomes.
Achieving precise in vivo targeting of mRNA remains a significant challenge in nanomedicine.

Purpose of the Study:

To establish a quantitative design framework for engineering organ-targeted mRNA delivery systems.
To define the formulation-biodistribution relationships of novel polymer-lipid integrated nanoparticles (PLINs).
To enable precise, organ-selective delivery of mRNA for various therapeutic applications.

Main Methods:

Integrated an I-optimal design-of-experiments (DOE) strategy with predictive regression modeling.
Developed a novel PLIN architecture using amphiphilic polyesters and cationic/ionizable lipids, excluding cholesterol and helper lipids.
Utilized a minimal set of 15 formulations to build predictive models linking formulation parameters to organ-specific mRNA expression.

Main Results:

Developed predictive regression models (R² > 0.96) quantifying formulation-biodistribution relationships for PLINs.
Achieved high organ selectivity, with up to 91% lung or 96% spleen targeting through model-guided optimization.
Identified key physicochemical determinants responsible for the observed organ-tropic behaviors of PLINs.

Conclusions:

A quantitative, model-driven framework enables the rational design of organ-targeted mRNA delivery systems.
The developed PLINs offer a versatile platform for precise mRNA delivery across diverse therapeutic contexts.
This approach establishes generalizable design rules for engineering advanced nanomedicines for targeted therapies.