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Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
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Updated: May 2, 2026

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Congrong Runtong oral liquid for functional constipation: A multicenter, placebo-controlled phase II trial.

Luqing Zhao1, Xiaohong Sun2, Lei Zhu3

  • 1Digestive Disease Center, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
|February 27, 2026
PubMed
Summary

Congrong Runtong Oral Liquid (CROL) effectively treats functional constipation in adults with Yang-deficiency type. The 6g/day dose showed significant improvement in bowel movements and was well-tolerated.

Keywords:
Cistanche deserticolaEfficacyFunctional ConstipationSafetyTraditional chinese medicine

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Area of Science:

  • Gastroenterology
  • Traditional Chinese Medicine
  • Clinical Pharmacology

Background:

  • Functional constipation (FC) is a common gastrointestinal disorder.
  • Yang-deficiency type FC is a specific subtype within Traditional Chinese Medicine (TCM) diagnostics.
  • Evaluating novel therapeutic agents for FC is crucial for improving patient outcomes.

Purpose of the Study:

  • To assess the efficacy and safety of Congrong Runtong Oral Liquid (CROL) in adult patients diagnosed with functional constipation of the Yang-deficiency type.
  • To compare the treatment response of CROL at two different dosages (3g/day and 6g/day) against a placebo.
  • To evaluate secondary outcomes including bowel movement frequency, stool consistency, and patient-reported symptoms.

Main Methods:

  • A multicenter, double-blind, placebo-controlled randomized clinical trial was conducted.
  • 180 adult participants meeting Rome IV and TCM Yang-deficiency criteria for FC were enrolled.
  • Participants were randomized to receive CROL (3g or 6g/day) or placebo for 8 weeks, with treatment response as the primary outcome.

Main Results:

  • The treatment response rate was significantly higher in the 6g/day CROL group (60.7%) compared to placebo (18.6%) (p < 0.0001).
  • The 3g/day CROL group also showed a statistically significant response rate (35.0%) versus placebo (p = 0.044).
  • Weekly complete spontaneous bowel movements (CSBMs) increased significantly with 6g/day CROL (p = 0.001) versus placebo. Treatment-related adverse events were low and comparable across groups.

Conclusions:

  • Congrong Runtong Oral Liquid (CROL) demonstrates significant efficacy in treating functional constipation of the Yang-deficiency type in adults.
  • The 6g/day dosage of CROL appears to be more effective than the 3g/day dosage.
  • CROL is a safe and well-tolerated treatment option for this patient population.