Related Experiment Video
Updated: Mar 1, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
Selective tumor accumulation as a route to precision medicine for platinum anticancer drugs
Erica J Peterson1, Nicholas P Farrell1
1Department of Chemistry, Virginia Commonwealth University, 1001 W. Main St., Richmond, VA 23284-2006, United States of America.
Abstract:
This brief review summarizes our work showing that glycosaminoglycans (GAGs) are mediators of platinum complex cellular accumulation. Especially, there is an inverse relationship whereby charged polynuclear platinum complexes exemplified by BBR3464 and BBR3571 show enhanced tumor accumulation and antitumor efficacy in presence of a high level of GAGs whereas the inverse relationship occurs for the neutral mononuclear carboplatin. These results add to our understanding of the tumor uptake of platinum anticancer drugs and suggest avenues toward precision medicine for platinums based on patient stratification.
More Related Videos
Related Concept Videos
Targeted Cancer Therapies
There are several types of targeted therapies against...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Modified-Release Drug Delivery Systems: Site-Targeted

