Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Association Areas of the Cortex01:21

Association Areas of the Cortex

10.0K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
10.0K
Cerebral Hemispheres01:05

Cerebral Hemispheres

2.7K
The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
2.7K
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

8.2K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
8.2K
Lateralization01:28

Lateralization

1.1K
Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
1.1K
Somatosensory, Motor, and Association Cortex01:23

Somatosensory, Motor, and Association Cortex

3.0K
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
3.0K
Facial Feedback Hypothesis01:24

Facial Feedback Hypothesis

713
Charles Darwin proposed that facial expressions are an evolutionary adaptation for communication. He argued that these expressions are not influenced by culture but are universal across species. For example, a snarling expression with exposed teeth signals a threat in many animals, including humans. Darwin also suggested that displaying an emotion can intensify the feeling. Smiling, for example, could enhance one's sense of happiness. This idea laid the foundation for understanding the role...
713

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Toward a transcriptomic framework for ultrasound neuromodulation: A perspective on gene expression and regional brain sensitivity.

Imaging neuroscience (Cambridge, Mass.)·2026
Same author

Empirical limitations of current low-intensity focused ultrasound simulation platforms.

Brain stimulation·2026
Same author

Anhedonia in patients with major depressive disorder (MDD): State-of-the-art consensus review.

Psychiatry research·2026
Same author

Simulated Reasoning and Self-Verification for Psychiatric Diagnosis in Generalist Large Language Models: Comparative Evaluation.

JMIR AI·2026
Same author

Targeted Connectomic Neuromodulation of the Orbitofrontal Cortex To Treat Obsessive-Compulsive Disorder.

medRxiv : the preprint server for health sciences·2026
Same author

Design and Recruitment for the Comparative Effectiveness of Zolpidem/Trazodone and Cognitive Behavioral Therapy for Insomnia (COZI) Study in Rural Adults.

Behavioral sleep medicine·2026

Related Experiment Video

Updated: Mar 1, 2026

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

7.7K

Rapid homotopic communication between human orbitofrontal subregions.

Clara Kwon Starkweather1, Ethan H Willbrand2, Kristin K Sellers3

  • 1Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, 132 Barker Hall, Berkeley, CA 94720, USA.

Current Biology : CB
|February 27, 2026
PubMed
Summary

The orbitofrontal cortex (OFC) shows homotopic interhemispheric connectivity. Medial OFC connects to medial OFC, and lateral OFC connects to lateral OFC, revealing organization principles in the human brain.

Keywords:
evoked potentialhomotopyhuman prefrontal cortexorbitofrontal cortexstimulation mapping

More Related Videos

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

46.6K
Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans
08:25

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

Published on: May 19, 2016

11.3K

Related Experiment Videos

Last Updated: Mar 1, 2026

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

7.7K
Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

46.6K
Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans
08:25

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

Published on: May 19, 2016

11.3K

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroanatomy

Background:

  • The orbitofrontal cortex (OFC) is crucial for decision-making, emotion, and pain processing.
  • While medial OFC is linked to value representation and lateral OFC to stimulus-outcome associations, interhemispheric communication in human OFC remains unclear.
  • Homotopic interhemispheric coupling is common in sensorimotor areas but less established in the human prefrontal cortex, including the OFC.

Purpose of the Study:

  • To investigate whether distinct subregions of the human orbitofrontal cortex (OFC) exhibit homotopic interhemispheric connectivity.
  • To map functional communication pathways between homologous regions in the left and right OFC.
  • To determine if known principles of cortical wiring apply to the human OFC.

Main Methods:

  • Utilized bilateral intracranial cortico-cortical evoked-potential (CCEP) mapping in humans.
  • Stimulated medial and lateral OFC subregions to record responses in contralateral homologous areas.
  • Analyzed short-latency responses to infer direct interhemispheric communication.

Main Results:

  • Demonstrated short-latency, homotopic interhemispheric connectivity across the medial/lateral axis of the human OFC.
  • Stimulation of medial OFC evoked rapid responses in the contralateral medial OFC.
  • Stimulation of lateral OFC evoked rapid responses in the contralateral lateral OFC.

Conclusions:

  • The human OFC exhibits homotopic organization, with distinct medial and lateral subregions communicating with their contralateral counterparts.
  • This finding extends the principle of homotopic cortical wiring into the evolutionarily expanded and anatomically variable human OFC.
  • The study reveals a fundamental organizational principle for interhemispheric communication within the human OFC.