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Lipid droplet-associated proteins: Roles in cardiovascular diseases

Zhongyang Yu1, Meng Zhao2, Hongyue Xu2

  • 1State Key Laboratory of Cardiovascular Diseases, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China; Shanghai Frontiers Center of Nanocatalytic Medicine, Tongji University, Shanghai, China; Department of Pathology and Pathophysiology, School of Medicine, Tongji University, Shanghai, China; Clinical Center for Heart Disease Research, Tongji University, Shanghai, China; Shanghai Arrhythmia Research Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China; Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Journal of Lipid Research
|February 27, 2026
PubMed

Insights

Lipid droplet-associated proteins (LDAPs) are crucial for maintaining lipid homeostasis in cardiovascular cells. This review systematically examines how LDAPs contribute to cardiovascular diseases (CVDs).

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiology

Background:

  • Cardiovascular diseases (CVDs) are a major global health concern.
  • Lipid metabolism is significantly altered in CVDs.
  • Lipid droplets (LDs) are key organelles involved in cellular lipid storage and metabolism.

Purpose of the Study:

  • To systematically review the role of lipid droplet-associated proteins (LDAPs) in cardiovascular diseases (CVDs).
  • To elucidate the association between LDAPs and the pathogenesis of CVDs.

Main Methods:

  • Literature review of studies investigating LDAPs and CVDs.
  • Analysis of the functions of specific LDAPs (e.g., PLINs, CIDEs, BSCL2, ABHD5, Rab18) in cardiovascular contexts.
  • Synthesis of current knowledge on LDAP involvement in lipid metabolism and CVDs.

Main Results:

  • LDAPs play a critical role in modulating lipid droplet homeostasis.
  • Dysregulation of LDAPs is implicated in the development and progression of various CVDs.
  • Specific LDAPs influence triglyceride and cholesterol metabolism within cardiovascular cells.

Conclusions:

  • LDAPs are significant contributors to cardiovascular disease pathogenesis.
  • Targeting LDAPs may offer novel therapeutic strategies for CVDs.
  • This review provides a comprehensive overview of LDAPs in CVDs, highlighting them as a key research area.

Keywords:
cardiovascular diseaseslipid dropletslipid droplets associated proteins

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