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Updated: Mar 1, 2026
05:56
Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
Published on: June 21, 2024
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Diuretic Administration for Vomiting During Concurrent Chemoradiotherapy for Cervical Cancer: A Multicenter
Naoya Tonomura1, Kensuke Yoshida2, Hajime Morita3
1Division of Hospital Pharmacy, Tokyo Metropolitan Tama Medical Center, Fuchu, Japan.
Anticancer Research
|February 27, 2026
Summary
Furosemide may be a better choice than mannitol for preventing chemotherapy-induced nausea and vomiting (CINV) during cervical cancer treatment. Furosemide was associated with less frequent and later onset of vomiting compared to mannitol in patients receiving chemoradiotherapy.
Area of Science:
- Oncology
- Pharmacology
- Gastroenterology
Background:
- Chemotherapy-induced nausea and vomiting (CINV) are significant challenges in cervical cancer concurrent chemoradiotherapy (CCRT).
- Mannitol and furosemide are used for cisplatin-induced nephrotoxicity, but their comparative effects on CINV are unknown.
Purpose of the Study:
- To evaluate the impact of mannitol versus furosemide on the incidence and timing of vomiting in cervical cancer patients undergoing CCRT.
Main Methods:
- A multicenter, retrospective study of 485 patients receiving weekly, cisplatin-based CCRT.
- Comparison of CINV outcomes between patients who received mannitol (n=206) and furosemide (n=279).
Main Results:
- Vomiting occurred more frequently in the mannitol group (18.4%) than the furosemide group (10.4%).
- Time-to-event analysis indicated earlier onset of vomiting with mannitol during CCRT.
Conclusions:
- Furosemide may be a more suitable option than mannitol for managing CINV risk in cervical cancer patients undergoing CCRT.
- Findings may relate to mannitol's osmotic properties and CCRT-induced intestinal permeability changes.
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