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Postoperative and Functional Outcomes of Oropharyngectomy in Irradiated Neck for Recurrent or Metachronous Squamous
Jade Saykaly1,2, Agnès Dupret-Bories1,2, Sébastien Vergez1,2
1Department of Surgery, University Cancer Institute of Toulouse-Oncopole, Oncopole Claudius Regaud, Université de Toulouse, Toulouse, France.
Objective:
To evaluate predictors of postoperative and functional outcomes following salvage oropharyngectomy.
Methods:
In this single-center retrospective study, we included all patients who underwent an oropharyngectomy in an irradiated neck for recurrent or metachronous cancer between 2014 and 2023.
Results:
We included 94 patients. The rate of complications was 53.2%, and was associated in multivariable analysis with tumor involving the midline (p = 0.001), oral cavity (p = 0.017) or glossotonsillar sulcus (p = 0.037), transcervical approach (p = 0.004), and high body mass index (p = 0.011). In multivariable analysis, high body mass index (p = 0.023), midline-crossing tumor (p = 0.022), and older age (p = 0.061) were associated with a hospital stay longer than 21 days. After a median follow-up of 74.3 months, 59.6% of patients had a gastrostomy. Predictors for this dependency in multivariable analysis were T3/T4 tumors (p = 0.06) and p16-status (p = 0.079).
Conclusions:
Salvage oropharyngectomy in irradiated neck remains associated with a complex postoperative course and a high morbidity.
