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Related Concept Videos

Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

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The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
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Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
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Related Experiment Video

Updated: Mar 1, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
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Appendiceal Tumors: A Narrative Review.

Alfredo Colombo1, Vittorio Gebbia2,3, Maria Rosaria Valerio4

  • 1Oncology Unit C.D.C. Macchiarella, Palermo, Italy; alfredocolombo63@gmail.com.

In Vivo (Athens, Greece)
|February 27, 2026
PubMed
Summary

Appendiceal tumors (ATs) are rare and challenging to diagnose. This review outlines diagnostic options, molecular diagnosis, staging, treatment, and prognostic markers for ATs.

Keywords:
Chemotherapyappendiceal cancerappendiceal surgerygastrointestinal stromal tumorsreviewtargeted therapy

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Area of Science:

  • Gastroenterology
  • Oncology
  • Pathology

Background:

  • Appendiceal tumors (ATs) are classified into four subtypes by the WHO.
  • Rarity and lack of randomized controlled studies make AT differentiation challenging.
  • Neuroendocrine neoplasms (NENs) are the most common histological type (54.6%).

Purpose of the Study:

  • To review diagnostic options for appendiceal tumors.
  • To discuss molecular-based diagnosis, staging, and treatment of ATs.
  • To outline prognostic markers for appendiceal tumors.

Main Methods:

  • Literature review of appendiceal tumors.
  • Analysis of WHO classification of digestive system tumors.
  • Synthesis of current knowledge on AT diagnosis and management.

Main Results:

  • ATs are often found incidentally during appendectomies for acute appendicitis.
  • Most ATs are benign or small NENs requiring no further treatment.
  • Appendiceal mucinous neoplasm (AMN) can lead to pseudomyxoma peritonei (PMP).

Conclusions:

  • Clinical diagnosis and management of ATs remain debated despite advances in cancer treatment.
  • A comprehensive understanding of ATs' diagnosis, staging, and treatment is crucial.
  • Further research is needed to improve AT management and patient outcomes.