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Updated: Mar 1, 2026
Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
Published on: November 28, 2015
Prognostic Superiority of the White Cell-to-Lymphocyte Ratio (WLR) in Predicting Overall Survival in Patients With
Xiao Zhang1, Guilan Cai1, Heyang Zhang2
1Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, P.R. China.
Background/Aim:
Systemic inflammation influences glioma progression. We evaluated the prognostic value of the white cell-to-lymphocyte ratio (WLR) and aiming to develop a practical survival prediction model.
Patients And Methods:
Patients with glioma from the INSCOC database were retrospectively analyzed and randomly split into training and validation cohorts (7:3). Kaplan-Meier analysis, restricted cubic splines, and Cox regression assessed associations between WLR and overall survival (OS). A WLR-based nomogram was established and internally validated using calibration and decision curve analysis.
Results:
The optimal WLR cutoff was 4.182. Patients with WLR ≥4.182 had significantly worse OS (p<0.01). Restricted cubic splines showed a positive dose-response relationship between WLR and mortality risk. In multivariable Cox analysis, age, smoking, drinking, and WLR group remained independent predictors of OS (all p<0.05). Sensitivity analyses confirmed robustness. The nomogram showed good discrimination and calibration for predicting 1-, 3-, and 5-year OS and provided greater net clinical benefit than individual clinical factors.
Conclusion:
WLR is an independent, readily available prognostic marker in glioma. A WLR-based nomogram may aid individualized risk stratification and clinical decision-making.
