Related Experiment Video
Updated: Mar 1, 2026

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
Published on: February 24, 2023
Melanoma-secreted melanosome-MHC I disrupts T cell antitumor immunity
1Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Abstract:
Classically, major histocompatibility complex class I (MHC I) molecules present tumor antigens to prime CD8+ T cell immunosurveillance and induce antitumor responses. Recently, Chemla et al. revealed a new immune evasion mechanism of melanoma by exporting peptide-loaded MHC I on secreted melanosomes to act as decoys that confuse and impair cytotoxic CD8+ T cells.
Related Concept Videos
The Tumor Microenvironment
Antigens Involved in Adaptive Immunity
Complete Antigens
Complete antigens possess both immunogenicity and...
Tumor Immunotherapy
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Abnormal Proliferation
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

