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Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Coronary Artery Disease I: Introduction01:30

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Peripheral Artery Disease I: Introduction01:30

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Related Experiment Video

Updated: Mar 1, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.8K

oxPAPC-Mediated lncRNA CYP1B1-AS1 From Dendritic Cells Accelerates Atherosclerosis.

Yuheng Cheng1,2, Lang Ni1, Changhao Ke2

  • 1Zunyi Medical University, Zunyi, China.

Journal of Cellular and Molecular Medicine
|February 27, 2026
PubMed
Summary

Oxidised 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (oxPAPC) induces dendritic cell (DC)-derived long non-coding RNAs (lncRNAs), accelerating atherosclerosis (AS). This study identified CYP1B1-AS1 as a key lncRNA promoting AS via a positive regulatory loop with NFATC2.

Keywords:
CYP1B1‐ASLncRNAatherosclerosisdendritic celloxPAPC

Related Experiment Videos

Last Updated: Mar 1, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.8K

Area of Science:

  • Molecular Biology
  • Immunology
  • Cardiovascular Research

Background:

  • Atherosclerosis (AS) involves oxidized lipids, dendritic cells (DCs), and long non-coding RNAs (lncRNAs).
  • The specific roles of oxPAPC-induced DC-derived lncRNAs in AS pathogenesis remain unclear.

Purpose of the Study:

  • To investigate the contribution of oxPAPC-induced DC-derived lncRNAs to AS.
  • To elucidate the regulatory mechanisms underlying this process.

Main Methods:

  • DCs were stimulated with oxPAPC, followed by transcriptomic analysis using RNA sequencing.
  • ChIP-Seq and RNA pull-down assays identified interactions between lncRNA CYP1B1-AS1 and NFATC2.
  • Murine models (Apoe-/- mice) were used to assess AS progression.

Main Results:

  • CYP1B1-AS1 was identified as a key oxPAPC-induced lncRNA in DCs, with its murine homologue Gm33055 enhancing Cyp1b1 expression.
  • oxPAPC promoted NFATC2 nuclear translocation, which binds to the CYP1B1-AS1 promoter; CYP1B1-AS1 then interacts with NFATC2, forming a positive feedback loop.
  • Adoptive transfer of DCs expressing m-CYP1B1-AS1 accelerated AS progression in Apoe-/- mice.

Conclusions:

  • A DC-derived lncRNA-mediated regulatory axis involving CYP1B1-AS1 and NFATC2 promotes atherosclerosis.
  • This axis represents a potential therapeutic target for AS treatment.