Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Capturing Cardiomyocyte Cell-to-Cell Heterogeneity via Shotgun Single Cell Top-Down Proteomics.

bioRxiv : the preprint server for biology·2026

Same author

Physical Activity and Cardiovascular Health.

Journal of diabetes research·2026

Same author

Emerging Technologies in Proteomics: Insights from the HUPO ETC Webinar Series.

Journal of proteome research·2026

Same author

Longitudinal proteomic and autoantibody signatures after mRNA vaccination in healthy individuals.

Vaccine·2025

Same author

A cross-sectional comparison of invasive and noninvasive aortic pulse wave velocity measurement in patients with or at risk for heart failure with preserved ejection fraction.

Cardiovascular diagnosis and therapy·2025

Same author

SCarP: Proteome Heterogeneity Characterization of Primary Mouse Cardiomyocytes.

Circulation research·2025

Same journal

The Immediate Impact of Infarct Size on the Systemic Inflammatory Response: IL-6 as Central Mediator Identified through Biomarker and Proteomic Profiling.

Journal of cardiovascular translational research·2026

Same journal

Extracellular Vesicles Link Cerebral Ischemia to Coronary Microvascular Dysfunction - Role for RGD Motif-Activated Endothelin Signaling.

Journal of cardiovascular translational research·2026

Same journal

Tracing the pathogenic PLN p.(Arg14del) variant across the globe; more than just a local curiosity.

Journal of cardiovascular translational research·2026

Same journal

Immunometabolic Remodeling in Ischemic and Non-Ischemic Heart Failure.

Journal of cardiovascular translational research·2026

Same journal

Left Ventricular Thrombus in Ischemic Heart Failure: Machine-learning-based Prediction of Six-month Persistence and One-year Outcomes.

Journal of cardiovascular translational research·2026

Same journal

Pim1 Mitigates Heart Failure by Suppressing Ferroptosis Via Activation of the mTORC1/SLC7A11/GPX4 Axis.

Journal of cardiovascular translational research·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 1, 2026

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

Published on: January 31, 2025

Takotsubo Syndrome: The First Non-Acute Proteomic Analysis by Remote Dried Blood Microsampling.

Paul Marano¹, Kirstin Washington^1,2,3, Blandine Chazarin^1,2,3

¹Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Journal of Cardiovascular Translational Research

|February 27, 2026

Summary

This summary is machine-generated.

This study reveals distinct protein profiles in individuals with prior Takotsubo syndrome (TTS) years after the acute event. These findings suggest potential underlying persistent heart changes, offering new insights into TTS pathophysiology.

Keywords:

Proteomics Stress cardiomyopathy Takotsubo syndrome

More Related Videos

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

Dynamic Proteomic and miRNA Analysis of Polysomes from Isolated Mouse Heart After Langendorff Perfusion

Dynamic Proteomic and miRNA Analysis of Polysomes from Isolated Mouse Heart After Langendorff Perfusion

Published on: August 29, 2018

Related Experiment Videos

Last Updated: Mar 1, 2026

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

Published on: January 31, 2025

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

Dynamic Proteomic and miRNA Analysis of Polysomes from Isolated Mouse Heart After Langendorff Perfusion

Dynamic Proteomic and miRNA Analysis of Polysomes from Isolated Mouse Heart After Langendorff Perfusion

Published on: August 29, 2018

Area of Science:

Cardiology
Proteomics
Biochemistry

Background:

Takotsubo syndrome (TTS) is a stress-induced heart condition with typically reversible function.
Long-term outcomes and the pathophysiology of non-acute TTS remain poorly understood.
Previous research has not characterized the proteomic landscape of non-acute TTS.

Purpose of the Study:

To investigate the proteomic differences between individuals with a history of TTS and healthy controls.
To identify potential biomarkers and pathophysiological pathways associated with long-term TTS.

Main Methods:

A case-control study utilizing mass-spectrometry-based discovery proteomics.
Analysis of remotely collected dried blood microsamples from 62 TTS participants and 47 controls.
Quantification of 398 unique proteins and pathway analysis of differentially regulated proteins.

Main Results:

Proteomic analysis successfully distinguished between TTS and control groups.
52 differentially regulated proteins were identified between the groups.
Enrichment analysis highlighted pathways involved in complement activation, nitric oxide signaling, and antioxidant activity.

Conclusions:

This study provides the first proteomic characterization of non-acute Takotsubo syndrome.
The identified protein pathways suggest a persistent cardiomyopathy associated with TTS.
These findings may indicate underlying mechanisms contributing to or resulting from TTS.