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Related Concept Videos

Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

Imaging Studies I: Kidney, Ureter, and Bladder Studies

489
Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
489

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Updated: Mar 1, 2026

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3D Whole-Kidney T1 Mapping Using Look-Locker Inversion Recovery in Conjunction With Balanced SSFP Readout and

Wenyan Zhang1,2, Zelong Chen3, Quan Tao1,2

  • 1School of Biomedical Engineering, Southern Medical University, Guangzhou, China.

Magnetic Resonance in Medicine
|February 27, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces dual breath-hold Look-Locker (Dual 3DLL) MRI for 3D whole-kidney T1 quantification. The validated technique accurately maps renal T1 values, offering a foundation for understanding kidney physiology.

Keywords:
T1 quantificationinversion recoverykidneymagnetic resonance imagingwhole‐kidney coverage

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Area of Science:

  • Magnetic Resonance Imaging
  • Medical Physics
  • Renal Physiology

Background:

  • Accurate T1 quantification is crucial for assessing renal function and disease.
  • Existing MRI techniques for whole-kidney T1 mapping face challenges in speed and coverage.
  • Developing robust 3D mapping methods is essential for comprehensive renal assessment.

Purpose of the Study:

  • To develop and validate a novel dual breath-hold Look-Locker inversion recovery (Dual 3DLL) MRI technique.
  • To achieve 3D whole-kidney T1 quantification using dictionary matching.
  • To establish a reliable method for renal T1 mapping.

Main Methods:

  • Dual 3DLL utilizes two breath-hold Look-Locker acquisitions with adiabatic inversion and 3D balanced SSFP readouts.
  • Retrospective image registration corrects for misalignment between breath-holds.
  • Bloch equation-based dictionary matching was employed for T1 quantification.

Main Results:

  • Phantom validation showed excellent agreement between Dual 3DLL and IRSE (2.5% CV, 4.3% relative error).
  • Feasibility in 11 healthy subjects demonstrated clinical applicability.
  • Whole-kidney T1 values from Dual 3DLL closely matched 2D MOLLI in renal cortex and medulla.

Conclusions:

  • 3D whole-kidney T1 mapping is feasible using the developed Dual 3DLL MRI technique.
  • The method combines Look-Locker T1-weighting, balanced SSFP, and dictionary matching.
  • This provides a technical foundation for advancing the understanding of renal pathophysiology.