Related Experiment Video

Updated: Mar 1, 2026

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
09:04

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

Published on: May 22, 2014

21.5K

Targeting the NLRP3 Inflammasome in Atherosclerosis: Advances in Anti-Inflammatory Therapies With Bioactive Natural

Haizhen Guo1,2, Shule Qian1, Yu Lu3

  • 1Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Phytotherapy Research : PTR
|February 27, 2026
PubMed

Insights

Natural products show promise for treating atherosclerosis (AS) by targeting the NLRP3 inflammasome pathway. Further research is needed to confirm their clinical efficacy and safety for cardiovascular and cerebrovascular diseases.

Area of Science:

  • Cardiovascular Research
  • Inflammation Biology
  • Natural Product Chemistry

Background:

  • Atherosclerosis (AS) is a primary factor in cardiovascular and cerebrovascular diseases.
  • The traditional cholesterol-focused model is insufficient, necessitating anti-inflammatory and lipid-lowering strategies.
  • The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a key target in AS, but FDA-approved treatments are lacking.

Purpose of the Study:

  • To review natural products as potential therapeutic agents for AS.
  • To evaluate natural products targeting NLRP3 inflammasome pathways in AS.
  • To identify gaps in current research and guide future clinical trials.

Main Methods:

  • A narrative review of publications from the past four years.
  • Searches conducted across major scientific databases: PubMed, Web of Science, EMBASE, Cochrane Library, and Scopus.
  • Focus on traditional Chinese medicine formulas, plant extracts, and natural compounds.

Main Results:

  • NLRP3 inflammasome signaling pathways play a critical role in AS development.
  • Evidence suggests various natural products can modulate NLRP3 inflammasome activity.
  • The review synthesizes findings on natural product interventions at different levels.

Conclusions:

  • Natural products offer a promising avenue for AS treatment due to their multi-target effects and safety profile.
  • High-quality, large-scale randomized controlled trials are essential to validate the clinical efficacy and safety of these natural products.
  • Addressing the unmet clinical need in AS management requires further investigation into natural product-based therapies.
Keywords:
NLRP3 inflammasomeatherosclerosisinflammationmechanismnatural products

More Related Videos

In vivo Near Infrared Fluorescence NIRF Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis09:43

In vivo Near Infrared Fluorescence NIRF Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis

Published on: August 4, 2011

18.6K
A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.8K

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
520
Inflammation01:38

Inflammation

Overview
62.8K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
1.6K
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
443
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
660