Development and Characterization of Candidate Vaccine Viruses Against High Pathogenicity Avian Influenza A(H5)
Li Wang1, Jieru Wang1, Jaber Hossain1
1Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Abstract:
High pathogenicity avian influenza A(H5) viruses pose a pandemic threat. These viruses have rapidly evolved in birds and frequently crossed species barriers, resulting in over 1000 confirmed human infections, with a case fatality proportion of approximately 50%. In response, the US Centers for Disease Control and Prevention (CDC) has developed dozens of A(H5) candidate vaccine viruses (CVVs) over the past 2 decades, primarily targeting clades known to infect humans. This report summarizes the development and characterization of the CVVs, with a particular focus on their antigenic relationships with clades 2.3.2.1e and 2.3.4.4b A(H5N1) viruses, which have been responsible for the majority of recent human infections.
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