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Related Experiment Video

Updated: May 5, 2026

Murine Model of Wound Healing

Murine Model of Wound Healing

Published on: May 28, 2013

NIR/pH-Responsive Multifunctional Hydrogel for Monitoring and Treating Diabetic Wounds.

Anqi Jin¹, Huaqian Xue^1,2, Zhiqiang Jia²

¹Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, Zhejiang, China.

Advanced Healthcare Materials

|February 28, 2026

Summary

This study introduces an intelligent hydrogel for chronic diabetic wound management. It enables real-time monitoring and on-demand treatment, accelerating wound healing in diabetic mice.

Keywords:

carbon quantum dots diabetes wound repair pH response photothermal hydrogel

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Published on: October 10, 2017

Area of Science:

Biomaterials Science
Regenerative Medicine
Nanotechnology

Background:

Chronic diabetic wounds present significant clinical challenges due to persistent infections and inflammation.
Current treatments often lack integrated monitoring and targeted therapeutic delivery.
A need exists for advanced wound management systems that can adapt to the wound microenvironment.

Purpose of the Study:

To develop an intelligent dual-light-responsive hydrogel for a closed-loop management system in chronic diabetic wounds.
To enable real-time wound monitoring and on-demand therapeutic intervention.
To evaluate the hydrogel's efficacy in promoting wound healing and tissue remodeling.

Main Methods:

Integration of pH-sensitive carbon dots and near-infrared (NIR)-active C@M nanozymes into a biocompatible hydrogel matrix.
Utilizing 365 nm light for non-invasive pH monitoring and NIR irradiation for therapeutic activation.
In vitro assessments of antibacterial activity, reactive oxygen species (ROS) scavenging, and macrophage polarization.
In vivo evaluation of wound closure, angiogenesis, and tissue remodeling in a diabetic mouse model.

Main Results:

The hydrogel successfully enabled real-time monitoring of wound acidification under 365 nm light.
NIR irradiation triggered antibacterial effects, ROS scavenging, and M2 macrophage polarization.
Molecular analysis showed upregulated VEGF expression and suppressed pro-inflammatory cytokines, indicating enhanced angiogenesis and tissue remodeling.
Significant acceleration of wound closure was observed in diabetic mice treated with the hydrogel.

Conclusions:

The developed intelligent hydrogel offers a precise and responsive strategy for chronic diabetic wound management.
The dual-light-responsive system effectively integrates sensing and therapeutic functions for a closed-loop approach.
This platform demonstrates potential for improved clinical outcomes in treating complex, non-healing wounds.