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Updated: Mar 1, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
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Signaling Pathway Remodeling and Molecular Regulation in the HCC TME: Dynamic Evolution and Clinical Therapeutic

Lin Xu1, Xuanhao Zhang1, Hengzhou Zhu1

  • 1Department of Oncology, Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine, 214071 Wuxi, Jiangsu, China.

Frontiers in Bioscience (Landmark Edition)
|February 28, 2026
PubMed

Keywords:
disease progressionhepatocellular carcinomaimmunotherapymolecular targeted therapysignal transductiontumor microenvironment

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