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Diverse Biological Functions of IGF2BPs in Hepatobiliary Cancers and Their Clinical Relevance

Zhijie Yin1, Qingfu Lang1, Peng Xiao2

  • 1Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, 150001 Harbin, Heilongjiang, China.

Frontiers in Bioscience (Landmark Edition)
|February 28, 2026
PubMed

Insights

Insulin-like growth factor 2 mRNA-binding proteins (IGF2BP1/2/3) are key regulators in hepatobiliary cancers. Targeting these m6A readers offers potential for precision diagnostics and novel therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Hepatobiliary malignancies are aggressive and difficult to treat.
  • N6-methyladenosine (m6A) is a crucial RNA modification regulating gene expression.
  • Insulin-like growth factor 2 mRNA-binding proteins (IGF2BP1/2/3) are key m6A readers.

Purpose of the Study:

  • To review IGF2BP-mediated regulatory mechanisms in hepatobiliary cancers.
  • To explore the translational potential of IGF2BPs as biomarkers and therapeutic targets.

Main Methods:

  • Comprehensive literature review of studies on IGF2BP function in cancer.
  • Analysis of IGF2BP roles in cancer hallmarks like proliferation, metastasis, and immune evasion.
  • Exploration of diagnostic and therapeutic strategies targeting IGF2BPs.

Main Results:

  • IGF2BP1/2/3 stabilize RNAs, influencing cancer-related signaling pathways.
  • Dysregulated IGF2BP expression correlates with tumor progression and treatment resistance.
  • IGF2BPs are implicated in proliferation, metastasis, metabolic adaptation, and immune evasion.

Conclusions:

  • IGF2BP proteins play significant roles in the development and progression of hepatobiliary cancers.
  • IGF2BP dysregulation presents opportunities for developing novel biomarkers and targeted therapies.
  • Targeting IGF2BP-mediated pathways could lead to improved precision diagnostics and interventions for hepatobiliary malignancies.
Keywords:
N6-methyladenosinegallbladder cancerhepatobiliary cancershepatocellular carcinomaintrahepatic cholangiocarcinomamolecular mechanismsnon-coding RNAtargeted therapy

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