Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

2.8K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
2.8K
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

2.2K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.2K
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

3.5K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advances in local field potential research in prolonged disorders of consciousness: a narrative review.

Chinese neurosurgical journal·2026
Same author

BTKi orelabrutinib improved the outcome of newly-diagnosed PCNS-LBCL by alleviating MyD88<sup>L265P</sup>-induced PIM1 stability.

Journal of hematology & oncology·2026
Same author

Physiological, Morphological, and Molecular Evaluation of Wheat Under Single (Drought, Salt, Heat) and Combined (Drought-Heat, Salt-Heat) Stress.

International journal of molecular sciences·2026
Same author

Control of Schwann Cell Myelination by DDR1 Receptor Tyrosine Kinase.

International journal of molecular sciences·2026
Same author

Tirzepatide attenuates doxorubicin-induced cardiotoxicity via mitochondrial function improvement.

Translational cancer research·2026
Same author

SLC2A3 Expression is Differentially Associated with Postoperative Recurrence, Complications, and Liver Metastasis in Colorectal Cancer.

Cancer management and research·2026

Related Experiment Video

Updated: Mar 1, 2026

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

12.9K

PDCD4: A Double-Edged Sword in Neurological Diseases.

Conghui Li1,2, Kang Zheng1, Mengsheng Qiu1

  • 1College of Life and Environmental Sciences, Key Laboratory of Organ Development and Regeneration of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, China.

Molecular Neurobiology
|February 28, 2026
PubMed
Summary

Programmed Cell Death 4 (PDCD4) has opposing roles in brain health, suppressing tumors but driving damage in neuroinflammation. Understanding its dual function is key for developing targeted therapies for brain diseases.

Keywords:
Dual roleGliomaNeurodegenerative diseasesNeurological diseasesPDCD4

More Related Videos

An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices
06:36

An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices

Published on: February 5, 2015

7.6K
Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
09:35

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Published on: May 19, 2020

11.0K

Related Experiment Videos

Last Updated: Mar 1, 2026

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

12.9K
An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices
06:36

An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices

Published on: February 5, 2015

7.6K
Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
09:35

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Published on: May 19, 2020

11.0K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Oncology

Background:

  • Programmed Cell Death 4 (PDCD4) exhibits context-dependent functions, acting as a tumor suppressor in gliomas and a detrimental factor in neuroinflammatory and degenerative diseases.
  • PDCD4 dysregulation is clinically significant, contributing to disease progression in both cancer and neurological conditions.
  • Its dual role is influenced by molecular environments, mRNA targets, and regulatory networks.

Purpose of the Study:

  • To elucidate the dualistic functions of Programmed Cell Death 4 (PDCD4) in neuro-oncology versus neuroinflammation and neurodegeneration.
  • To understand the molecular mechanisms governing PDCD4's context-specific roles and dysregulation.
  • To identify therapeutic strategies targeting PDCD4 for brain disorders.

Main Methods:

  • Analysis of PDCD4 regulation in glioma (e.g., promoter methylation, miR-21 inhibition, FAT1-STAT1 axis).
  • Investigation of PDCD4's role in neural injury and neurodegeneration (e.g., MAPK/NF-κB, NLRP3 inflammasome, apoptosis, ferroptosis, BDNF suppression).
  • Examination of regulatory networks including miRNA, epigenetics, and ceRNA mechanisms.

Main Results:

  • In gliomas, PDCD4 downregulation impairs anti-tumor functions, including cell cycle arrest and apoptosis.
  • In neurodegenerative conditions, PDCD4 upregulation promotes inflammation, neuronal death, and hinders repair by suppressing neurotrophic factors.
  • A complex regulatory network, particularly involving miR-21, controls PDCD4's expression and activity.

Conclusions:

  • PDCD4's opposing roles in brain diseases necessitate context-specific therapeutic approaches.
  • Further research is required to fully understand PDCD4 regulatory synergies, cell-type-specific functions, and interactions.
  • Multi-omics and cell-specific tools are crucial for deciphering PDCD4 mechanisms and developing targeted treatments.