Related Experiment Video
Updated: Mar 1, 2026
Probiotic Studies in Neonatal Mice Using Gavage
Published on: January 27, 2019
Probiotic Supplementation and Its Impact on Atopic Dermatitis and Related Conditions in Infants and Children: An
Zahra Rafiei1, Haniyeh Azadi1, Parvin Dehghan2
1Student Research Committe, Tabriz University of Medical Sciences, Tabriz, Iran.
Insights
Probiotic supplementation significantly reduces atopic dermatitis (AD) severity and eczema in infants. While beneficial for AD and eczema, probiotics did not show a link to IgE levels, wheezing, allergies, or asthma.
Area of Science:
- Pediatric Allergy and Immunology
- Gastroenterology
- Nutritional Science
Background:
- Atopic dermatitis (AD) is a common condition in infants and children.
- Probiotic supplementation is increasingly studied for its potential benefits in managing atopic diseases.
- Previous meta-analyses on probiotics for AD have yielded uncertain results.
Purpose of the Study:
- To conduct an umbrella meta-analysis assessing the efficacy of probiotic supplementation on atopic dermatitis and other atopic manifestations in pediatric populations.
- To synthesize findings from multiple existing meta-analyses to provide a comprehensive overview of probiotic effects.
Main Methods:
- Systematic literature search across major databases (PubMed, Scopus, etc.) up to September 2024.
- Inclusion of 22 meta-analyses meeting predefined criteria.
- Utilized random-effects or fixed-effects models based on heterogeneity and assessed meta-analysis quality using AMSTAR2.
Main Results:
- A significant decrease in atopic dermatitis severity (WMD = -4.16) and eczema (ES = 0.75) was observed in infants.
- Subgroup analyses indicated no significant heterogeneity from probiotic type, sample size, duration, or population characteristics.
- No statistically significant association was found between probiotic use and IgE levels, wheezing, allergies, or asthma.
Conclusions:
- Probiotics demonstrate a beneficial role in managing atopic dermatitis and eczema in infants.
- Current evidence does not support a link between probiotic use and improved outcomes for IgE levels, wheezing, allergies, or asthma.
- Further research may be warranted to explore specific probiotic strains and their targeted effects in pediatric atopic conditions.
Abstract:
Growing evidence has suggested that probiotic consumption can decrease the incidence of Atopic dermatitis (AD) in infants and children. However, even meta-analyses have reported uncertain findings. The current umbrella meta-analysis aimed to assess the findings of multiple meta-analyses on the efficacy of probiotic supplementation on AD and other atopic manifestations in infants and children. A systematic search of the Literature was carried out in PubMed, ISI Web of Knowledge, Scopus, Cochrane Central Library, EMBASE, and Google Scholar from inception up to September 2024. Random-effects model was utilized when there was a significant between-study heterogeneity; otherwise, fixed-effects model was employed. The quality of the selected meta-analyses was assessed using a measurement tool to assess multiple systematic reviews 2 (AMSTAR2). Of the 1302 articles identified in the search, 22 articles that met the criteria were included in the present comprehensive umbrella meta-analysis. Findings indicated a notable decrease in AD severity based on WMD (ES = -4.16; 95%CI: -6.75, -1.57, p < 0.000) and Eczema (ES = 0.75; 95% CI: 0.69,0.81, p < 0.000) among infants. Subgroup analysis showed that factors such as type of probiotic, sample size, duration, and population were not significant sources of heterogeneity. Our research suggests that probiotics could play a beneficial role in managing AD and eczema. However, we found no statistically significant link between probiotic use and IgE levels, wheezing, allergies, or asthma.
More Related Videos
05:31Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
09:36Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
Published on: July 28, 2022
Related Concept Videos
01:23Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
01:23Anatomy of the Intestines
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
01:29Microorganisms in Medicine and Therapeutics