Treatable traits and treatment options in asthma

Area of Science:

• Pulmonology
• Internal Medicine
• Genetics

Background:

• Asthma management is evolving towards personalized medicine.
• Asthma is now understood as a heterogeneous disease with complex underlying biological processes.
• Severe and difficult-to-treat asthma are increasingly manageable with new therapeutic approaches.

Purpose of the Study:

• To review the concept of treatable traits in asthma.
• To discuss the pathology, diagnosis, and management of these traits.
• To provide a structured approach for holistic severe asthma care.

Main Methods:

• Literature review of current evidence on asthma treatable traits.
• Analysis of biological processes and inter-relationships with other diseases.
• Survey of current evidence gaps and future research directions.

Main Results:

• Asthma management is shifting from a one-size-fits-all approach to personalized strategies.
• Identification and management of specific biological processes (treatable traits) are key to effective asthma control.
• Understanding comorbidities and their impact on asthma is crucial.

Conclusions:

• A treatable traits approach offers a structured framework for managing severe asthma.
• Personalized medicine, focusing on individual biological processes, enhances therapeutic efficacy.
• Further research is needed to address evidence gaps and develop targeted treatments for severe asthma.