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A closed-loop microfluidic platform for enhanced gut organoid maturation via physicochemical control and

Eric Kwame Owusu1, Donatien Sinzinkayo1, Yue Wang2

  • 1School of Mechatronics Engineering and Automation, Shanghai University, Shanghai, China.

Gene
|February 28, 2026
PubMed
Summary

This study introduces an advanced organoid-on-chip platform with real-time monitoring and autonomous control of the microenvironment, significantly improving organoid health and differentiation for disease modeling and drug screening.

Keywords:
Closed-loop MicrofluidicsGut organoidsMicroenvironmentMorphodynamic sensorOrganoid-on-ChipPhysicochemical control

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