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Preliminary Study on Optimizing the Malignant Risk Stratification Model of Gallbladder Polyps Based on CEUS
Jianfei Chen1, Zhidan Geng2, Congyu Tang3
1Department of Ultrasound, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Department of Ultrasound, Zhongshan Hospital of Fudan University, Shanghai, China.
Ultrasound in Medicine & Biology
|February 28, 2026
Summary
Contrast-enhanced ultrasound (CEUS) significantly enhances the accuracy of gallbladder polyp (GBP) malignancy risk assessment. Integrating CEUS features into ultrasound models improves diagnostic performance for better clinical application.
Area of Science:
- Medical Imaging
- Gastroenterology
- Oncology
Background:
- Gallbladder polyps (GBPs) require accurate risk stratification for malignancy.
- Conventional ultrasound (US) has limitations in differentiating benign from malignant GBPs.
- Contrast-enhanced ultrasound (CEUS) offers enhanced visualization of tissue perfusion.
Purpose of the Study:
- To evaluate if CEUS features improve the diagnostic performance of US-based malignant risk stratification models for GBPs.
- To compare the efficacy of conventional US, simplified CEUS, and multiparametric CEUS models.
- To assess the clinical utility of CEUS in GBP evaluation.
Main Methods:
- Prospective enrollment of 300 patients with GBPs undergoing surgery.
- Pre-operative conventional US and CEUS examinations.
- Development of a simplified CEUS model and a multiparametric CEUS model incorporating perfusion characteristics.
- Comparison of diagnostic efficacy against surgical pathology as the gold standard.
Main Results:
- Eight CEUS indicators showed excellent inter-observer consistency.
- The multiparametric CEUS model demonstrated superior diagnostic performance compared to US and simplified CEUS models.
- Area under the ROC curve values for differentiating benign vs. malignant polyps were 0.893 (US), 0.974 (simplified CEUS), and 0.983 (multiparametric CEUS).
Conclusions:
- Incorporating CEUS features significantly enhances the diagnostic efficacy of malignant risk stratification for GBPs.
- The multiparametric CEUS model offers high clinical value for GBP evaluation.
- CEUS is a valuable tool that warrants widespread clinical application for gallbladder polyp assessment.
