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SOHO State of the Art Updates and Next Questions | Addressing the Transformative Questions in Aggressive B-Cell
Gonca Ozcan1, Mark Roschewski1
1Lymphoid Malignancies Branch, Center for Cancer Research, NCI, Bethesda, MD.
None:
Large B-cell lymphoma (LBCL) is a heterogeneous disease for which anthracycline-based chemoimmunotherapy cures most patients. However, a substantial minority of patients experience refractory disease or relapse, and outcomes remain poor. Improving frontline cure rates therefore remains a fundamental objective in the lymphoma field and has led to the development of multiple therapeutic strategies. Herein, we discuss approaches aimed at improving outcomes beyond standard chemotherapy and address 4 transformative questions in LBCL: (1) can immunotherapy improve frontline cure rates; (2) is precision medicine a sound approach to overcome genetic heterogeneity; (3) can LBCL be cured without chemotherapy; (4) can circulating tumor DNA (ctDNA) aid clinical decision-making in response-adapted strategies. Together, these approaches reflect evolving strategies that may improve frontline outcomes and inform future treatment paradigms for patients with LBCL.
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