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Genetic polymorphism of C'3(beta1C-globulin) in human serum
Science (New York, N.Y.)
|November 22, 1968
Insights
Genetic variations in the third component of human complement (C3) were identified using electrophoresis. This study found six C3 phenotypes in Caucasians, inherited through four codominant alleles.
Area of Science:
- Immunogenetics
- Human Complement System
Background:
- The third component of complement (C3) is crucial for immune responses.
- Understanding C3 genetic polymorphism aids in studying human populations and disease associations.
Purpose of the Study:
- To investigate the genetic polymorphism of the human complement component C3.
- To determine the inheritance patterns and allele frequencies of C3 in a Caucasian population.
Main Methods:
- High-voltage starch-gel electrophoresis was employed to analyze C3 and its breakdown products in human serum.
- A cohort of 113 randomly selected Caucasians was studied.
Main Results:
- Six distinct C3 phenotypes were identified.
- The inheritance of C3 phenotypes is controlled by four codominant autosomal alleles.
- Observed gene frequencies were C3(1)=0.21, C3(2)=0.77, C3(3)≈0.01, and C3(4)≈0.004.
Conclusions:
- The human C3 genetic system exhibits significant polymorphism.
- The identified alleles and their frequencies provide a genetic profile for the studied Caucasian population.
Abstract:
Genetic polymorphism of the third component of human complement and its breakdown products has been detected in human serum by high-voltage starch-gel electrophoresis. Six phenotypes were observed in a study of 113 randomly chosen Caucasians. Their inheritance is controlled by four codominant alleles at an autosomal locus. The gene frequencies in this study were C3(1), 0.21; C3(2), 0.77; C3(3), approximately 0.01; and C3(4), approximately 0.004.