Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

6.2K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
6.2K
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

7.2K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
7.2K
Structure of Lipids03:38

Structure of Lipids

100.1K
Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic...
100.1K
Structure of Lipids03:38

Structure of Lipids

14.2K
14.2K
Lipids as Anchors01:32

Lipids as Anchors

7.7K
In the plasma membrane, the lipids forming the bilayer can also act as an anchor to tether proteins to the membrane. The three main types of lipid anchors found in eukaryotes are – prenyl groups, fatty acyl groups, and glycosylphosphatidylinositol or GPI groups. Prenyl and fatty acyl groups act as anchors on the cytosolic surface of the membrane, whereas GPI anchors proteins on the extracellular side.
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains...
7.7K
Lipid Digestion01:06

Lipid Digestion

101.0K
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
101.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization and Bioactivity of Nanovesicles Recovered From Industrial Cheesemaking Whey Wastewater.

Journal of food science·2026
Same author

Integrated analysis of insulin resistance reveals metabolic remodeling following diet switch-triggered calorie reduction.

Science advances·2026
Same author

Extracellular Vesicles from <i>Capparis spinosa</i> Modulate Epithelial-to-Mesenchymal Transition in Huh7 Hepatocellular Carcinoma Cells.

Nanomaterials (Basel, Switzerland)·2026
Same author

Multiomics characterization of acute child illness and mortality in Africa and South Asia.

Nature communications·2026
Same author

Multi-parametric profiling of plasma-derived extracellular vesicles reveals a disease-associated molecular signature supporting a liquid biopsy approach in myelofibrosis.

Molecular medicine (Cambridge, Mass.)·2026
Same author

Lipidomic and metabolomic analysis of human erythrocytes during storage for transfusion applications.

Blood transfusion = Trasfusione del sangue·2026

Related Experiment Video

Updated: Mar 2, 2026

Sample Preparation for Rapid Lipid Analysis in Drosophila Brain Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging
09:00

Sample Preparation for Rapid Lipid Analysis in Drosophila Brain Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

Published on: July 14, 2022

3.8K

Functional lipid analysis via index-based lipidomics profile: a new computational module in LipidOne.

Husam B R Alabed1, Dorotea Frongia Mancini2, Martina Pergola2

  • 1Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.

Bioinformatics (Oxford, England)
|March 1, 2026
PubMed
Summary

LipidOne

More Related Videos

Shotgun Lipidomics of Rodent Tissues
11:46

Shotgun Lipidomics of Rodent Tissues

Published on: November 18, 2022

2.7K
Lipidomics and Transcriptomics in Neurological Diseases
09:58

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

4.1K

Related Experiment Videos

Last Updated: Mar 2, 2026

Sample Preparation for Rapid Lipid Analysis in Drosophila Brain Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging
09:00

Sample Preparation for Rapid Lipid Analysis in Drosophila Brain Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

Published on: July 14, 2022

3.8K
Shotgun Lipidomics of Rodent Tissues
11:46

Shotgun Lipidomics of Rodent Tissues

Published on: November 18, 2022

2.7K
Lipidomics and Transcriptomics in Neurological Diseases
09:58

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

4.1K

Area of Science:

  • Biochemistry
  • Systems Biology
  • Bioinformatics

Background:

  • Understanding lipid functional roles is crucial for metabolic phenotype interpretation in health and disease.
  • Current lipidomic analyses often lack systems-level insights due to a focus on individual lipid species.
  • Translating quantitative lipidomic data into biologically structured, function-oriented interpretations remains a challenge.

Purpose of the Study:

  • To introduce a novel analytical module, Functional Lipid Analysis (FLA), integrated into the LipidOne platform.
  • To enable the translation of quantitative lipidomic data into biologically structured and function-oriented interpretations.
  • To provide a tool for deeper mechanistic and systems-level insights into lipid metabolism.

Main Methods:

  • The Functional Lipid Analysis (FLA) module computes 42 indices related to lipid functions (membrane structure, energy storage, signaling).
  • Indices are derived from lipid class and fatty acyl-, alkyl-, and alkenyl-chain composition.
  • Statistical comparisons across experimental groups and multivariate/visualization tools are employed for exploration.

Main Results:

  • FLA computes 42 functional lipid indices from compositional data.
  • Each index is semantically annotated and linked to predicted protein mediators for pathway/network interpretation.
  • Application to published datasets confirmed prior findings and revealed novel, biologically coherent functional insights.

Conclusions:

  • The new FLA module enhances LipidOne, providing a powerful tool for functional lipid analysis.
  • FLA facilitates pathway- and network-based interpretation of lipidomic data.
  • This approach advances the understanding of lipid roles in biological systems.