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Related Concept Videos

General Case of Eccentric Axial Loading01:12

General Case of Eccentric Axial Loading

554
Unsymmetrical bending occurs when the bending moment applied to a structural member does not align with its principal axis. This misalignment leads to complex stress distributions and deflection patterns that differ from symmetrical bending, which are essential for designing structures to withstand different loading conditions.
Consider a member subjected to equal and opposite forces that are applied along a line that does not coincide with the member's neutral axis. In unsymmetrical...
554

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Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
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Mechanical Load-Capacity Models for Bone in Youth - Analysis of Risk Signatures.

Marília Marques1,2, Paula Bruno1, Filomena Vieira1

  • 1CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, Portugal.

Journal of Musculoskeletal & Neuronal Interactions
|March 1, 2026
PubMed
Summary
This summary is machine-generated.

Low lean mass, both structural (appendicular lean soft tissue index) and functional (handgrip strength), is linked to reduced bone mineral density in adolescents. Monitoring lean soft tissue is crucial for adolescent bone health.

Keywords:
Bone Mineral DensityFat MassHandgrip StrengthLean Body MassNHANES

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Area of Science:

  • Pediatric Endocrinology
  • Bone Health Research
  • Adolescent Health

Background:

  • Mechanical load influences bone development.
  • Lean soft tissue plays a role in skeletal health.
  • Understanding factors affecting bone mineral density in adolescents is critical.

Purpose of the Study:

  • To investigate the association between structural and functional lean mass and bone mineral density in adolescents.
  • To examine relationships between appendicular lean soft tissue index (ALSTI), trunk fat mass (TrFM), and handgrip strength (HGS) with whole-body bone mineral density less head (WBLH BMD) and arms/legs BMD imbalance.

Main Methods:

  • Analysis of cross-sectional NHANES data from 5,424 adolescents (10-19 years).
  • Measurement of ALST, TrFM, and BMD using dual-energy X-ray absorptiometry.
  • Assessment of HGS using a dynamometer; standardization of variables by sex and age group (Z-scores).

Main Results:

  • Low ALSTI was associated with higher odds of low WBLH BMD in both girls and boys.
  • Low HGS was also linked to increased odds of low WBLH BMD in adolescent girls and boys.
  • Low HGS/body mass showed significantly higher odds of arms/legs BMD imbalance in both sexes, particularly in girls.

Conclusions:

  • Deficits in both structural and functional lean mass are associated with compromised bone mineral density and imbalance in adolescents.
  • These findings highlight the importance of lean soft tissue assessment for monitoring adolescent bone health.
  • Targeting lean mass development may be a strategy to improve skeletal integrity in young populations.