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Acquired bisalbuminemia associated with hepatobiliary disease: a two-case report and diagnostic implications
Reda Karami1,2, Fatima El Boukhrissi1,2
1Biochemistry-Toxicology Laboratory, Moulay Ismail Military Hospital, Meknes, Morocco.
Introduction:
Acquired bisalbuminemia is an uncommon qualitative albumin abnormality increasingly detected by capillary electrophoresis. It can be associated with several pathologic contexts.
Methods:
A retrospective analysis was performed on two cases of bisalbuminemia detected over a 10-year period in the biochemistry-toxicology laboratory of Moulay Ismail Military Hospital in Meknes, Morocco. Clinical, biochemical, electrophoretic, and histologic data were reviewed, with particular emphasis on serum albumin electrophoretic patterns.
Results:
Bisalbuminemia was identified in two distinct hepatobiliary contexts: an overlap syndrome between autoimmune hepatitis and primary sclerosing cholangitis and antibiotic exposure in a patient with cholangiocarcinoma. In both cases, the abnormal albumin fraction was temporary and resolved after treating the underlying condition or withdrawing the drug that was causing it.
Discussion:
Acquired bisalbuminemia represents a reversible laboratory finding that reflects underlying pathologic or pharmacologic processes. Capillary electrophoresis plays a pivotal role in the detection and follow-up of this condition.
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