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Updated: Mar 3, 2026

Author Spotlight: Development and Characterization of Eco-Friendly Lignin-Based Microparticles for Enhanced Delivery of Bioflavonoids
Published on: March 1, 2024
Enhancing bioavailability of morin via multi-particulate dosage forms: Development and pharmacokinetic insights
Dhrumi Patel1, Sarika Wairkar1
1Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai, 400056 Maharashtra, India.
Objectives:
Morin (MOR), a multidimensional flavonoid, has poor solubility and oral absorption. The present study aims to prepare MOR immediate (IR) and sustained release (SR) multi-particulate dosage forms (pellets) and evaluate their oral pharmacokinetics in rats.
Methods:
MOR oral pellets were formulated via extrusion-spheronization technique using microcrystalline cellulose as spheronization aid and HPMC-K4M and Pluronic-F127 as SR polymers.
Results:
The ATR-FTIR data indicated compatibility of MOR with the excipients used in pellets. The SEM data demonstrated the spherical shape of pellets, whereas the DSC results indicated reduced crystallinity of MOR. Based on in vitro drug release of MOR pellets, MOR-03 batch exhibited IR (98.49±0.17%, 1h), whereas MOR-06 showed SR (96.45±1.89%, 24h). The pharmacokinetic study illustrated a 2.64-fold and 2.77-fold enhanced maximum drug plasma concentration (Cmax) for MOR-IR and MOR-SR pellets whereas 2-fold (MOR-IR pellets) and 8-fold (MOR-SR pellets) improved area under the curve (AUC) compared to MOR-API group.
Conclusion:
IR and SR pellets could enhance oral absorption of MOR and offer cost-effective, scalable alternative for oral delivery of MOR.
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