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Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...

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[Development and Evaluation of At-211 Labeled Peptides].

Kazuma Ogawa1

  • 1Graduate School of Medical Sciences, Kanazawa University.

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|March 1, 2026
PubMed
Summary
This summary is machine-generated.

Astatine-211 (211At) shows promise for targeted alpha therapy (TAT) due to its properties. This review covers developing 211At-labeled peptides, like RGD peptides, for potential radiotheranostics.

Keywords:
albumin binding moietyarginylglycylaspartic acid (RGD) peptideastatine-211 (211At)peptideradiotheranosticstargeted alpha therapy (TAT)

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Area of Science:

  • Nuclear medicine
  • Radiochemistry
  • Oncology

Background:

  • Astatine-211 (211At) is a promising alpha-emitter for targeted alpha therapy (TAT).
  • Its properties allow adaptation of radioiodination techniques for radiotheranostics.
  • 211At's short half-life suits tumor-targeting molecules.

Purpose of the Study:

  • To review the development of 211At-labeled peptides for TAT.
  • To highlight the use of arginylglycylaspartic acid (RGD) peptide as a model targeting ligand.

Main Methods:

  • Review of existing literature on 211At radiolabeling techniques.
  • Focus on methods applicable to peptide labeling.
  • Discussion of RGD peptide as a targeting moiety.

Main Results:

  • 211At labeling is feasible using established radioiodination methods.
  • Peptide-based targeting agents can be effectively labeled with 211At.
  • RGD peptides demonstrate potential for 211At delivery to target sites.

Conclusions:

  • 211At is a viable radionuclide for TAT, offering radiotheranostic potential.
  • 211At-labeled peptides, such as RGD, are promising for targeted cancer therapy.
  • Further development is needed to optimize 211At-based radiopharmaceuticals.