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Related Experiment Video

Updated: Mar 3, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
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Nailfold Capillary Changes in Primary Hyperparathyroidism.

Ahmet Ozcan1, Hakan Korkmaz1, Rahime Cankat Gurel2

  • 1Department of Internal Medicine, Division of Endocrinology, Faculty of Medicine, Suleyman Demirel University, Isparta, Türkiye.

Clinical Endocrinology
|March 2, 2026
PubMed
Summary
This summary is machine-generated.

Patients with primary hyperparathyroidism (PHPT) exhibit significant nailfold capillary changes. These microvascular alterations are linked to parathormone (PTH) and calcium levels, suggesting PHPT impacts peripheral circulation.

Keywords:
capillaroscopydermatoscopymicrocirculationprimary hyperparathyroidism

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Area of Science:

  • Endocrinology
  • Vascular Biology
  • Dermatology

Background:

  • Primary hyperparathyroidism (PHPT) is a common endocrine disorder.
  • Cardiovascular complications are recognized in PHPT.
  • Peripheral microcirculation changes in PHPT are less understood.

Purpose of the Study:

  • To evaluate nailfold capillary morphology in PHPT patients.
  • To investigate associations between capillary changes and serum parathormone (PTH) and calcium levels.

Main Methods:

  • Cross-sectional study involving 62 PHPT patients and 34 controls.
  • Digital dermatoscopy used for nailfold capillary assessment.
  • Serum levels of calcium, PTH, and other biochemical markers measured.

Main Results:

  • PHPT patients showed significantly higher prevalence and scores of minor morphological changes (MiMC) in nailfold capillaries.
  • Avascular area scores (AAS) correlated positively with PTH, calcium, and age.
  • Serum calcium independently associated with MiMC; PTH and age independently influenced AAS.

Conclusions:

  • Microvascular alterations are present in the nailfold capillaries of PHPT patients.
  • PHPT may affect peripheral microcirculation at the capillary level.
  • Findings expand understanding of PHPT's systemic effects beyond cardiovascular involvement.