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Gingival Melanin Depigmentation Using Pulsed 450 nm Diode Laser: A Split-Mouth Randomized Clinical Trial Comparing
Walid Altayeb1, Kenneth Luk2, Arnabat-Dominguez Josep3
1Master Laser Dentistry, Università Cattolica del Sacro Cuore di Roma, Rome, Italy.
Photobiomodulation, Photomedicine, and Laser Surgery
|March 2, 2026
Summary
Ablative and non-ablative 450 nm diode lasers effectively remove gingival pigmentation. Ablative lasers offer immediate results with higher discomfort, while non-ablative lasers provide greater comfort but require more sessions for comparable outcomes.
Area of Science:
- Dental Aesthetics
- Laser Dentistry
Background:
- Gingival pigmentation is a prevalent esthetic concern impacting patient confidence.
- Laser-assisted depigmentation is a popular treatment option.
- Limited comparative data exists for ablative versus non-ablative laser techniques.
Purpose of the Study:
- To compare clinical outcomes of gingival depigmentation using ablative and non-ablative 450 nm diode lasers.
- To evaluate patient comfort levels associated with each laser technique.
Main Methods:
- A split-mouth, single-blind, randomized controlled trial involving 20 patients.
- Comparison of ablative and non-ablative 450 nm diode lasers on contralateral sides.
- Assessment of Dummett Oral Pigmentation Index (OPI) and Melanin Pigmentation Index over 12 months.
- Evaluation of patient-reported pain and discomfort using a modified McGill Pain Questionnaire.
Main Results:
- Both laser techniques successfully reduced gingival pigmentation.
- Ablative lasers provided immediate results with lower repigmentation rates but higher intraoperative discomfort.
- Non-ablative lasers resulted in less pain and faster healing but needed multiple sessions for comparable efficacy.
- Significant differences were observed in repigmentation rates and patient comfort.
Conclusions:
- Both ablative and non-ablative 450 nm diode lasers are effective for gingival depigmentation.
- Treatment choice depends on patient preference: ablative for immediate results, non-ablative for enhanced comfort.
- Tailoring the technique to patient needs optimizes outcomes for esthetic concerns.

